How to Beat Netherbrain in Baldur’s Gate 3
The Netherbrain is the last fraction in Baldur’s Gate 3, which players have to act against to complete the game. This psychophilic overmind governs the Illithids (Mind Flayers) and organizes itself for the purpose of enslaving entire populations of worlds. Fighting with Netherbrain is, in some way, not only a battle but also the result of all the choices and friendships made during the whole gameplay.
This BG3 Netherbrain boss guide includes all you need to know about the preparation process, staking, strategies, and basically all you need to know to defeat this Baldur's Gate 3 final boss – Netherbrain at the final stage of the game. We will also discuss the party composition, their abilities, and things to look at during the onslaught.

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Staging for the Netherbrain Fight
1. Party Composition
Of course, the Netherbrain cannot be defeated without having a balanced group that has proper tank/artifact users, DPS, and healers. Here’s an ideal setup for this battle:
- Tank: A Fighter, Barbarian, or Paladin is going to be needed to prevent the summoned creatures from getting through during the fight. Due to high health and defensive stats, those damage dealers can concentrate on taking out the Netherbrain without being bothered.
- Damage Dealers: Sorcerers, Warlocks, or Rangers will be important players in dealing with damage from range. There must always be characters who can dish out as well as receive punishment from a distance.
- Support: A Cleric or Druid also has the capability of healing, buffing, and popular crowd control, and if applied, it will help your party stay alive during the battle. Most of the time, this is a battle of endurance, which means that Bless, Healing Word, and Mass Cure Wounds are spells that your team cannot afford to be without.
2. Buff Spells and Potions
While fighting Netherbrain Baldur's Gate 3, ensure that the party is invulnerable from any attack by using magic such as Bless, Haste, and Protection from Evil and Good. It can deliver substantial bonuses, often adding a spell that includes applying bonuses to attack rolls and additional actions to defend against particular enemies.
Always prepare a potion to cure light wounds, two potions of Restoration (for the removal of negative level effects), and scrolls containing the spell of heal or a buffing spell.
Netherbrain’s Skills
The Netherbrain is a formidable enemy for fans of turn-based battles. It will constantly use a range of maneuvers and strikes against the party. It is important to have strategies for preventing or dealing with it in order to come out victorious.
1. Mind Control
As the leader of the Illithids, the Netherbrain has mind control, so expect some of your allies to stab you in the back. This isn’t good since it can easily disrupt your plans and lead to tremendous losses in the end.
Countering Mind Control: To prevent that manipulation, protect the foreseen key characters from evil and good spells. This spell lowers the chances of being charmed, frightened, or possessed by the psychic powers of the Netherbrain.
2. Psychic Trauma and Area of Effect Attacks
The Netherbrain’s primary source is psychic damage, which targets the whole party if they are clustered together. Such Area of Effect (AoE) attacks are very effective. They can even inflict a large amount of damage and possibly stun characters with a lower health bar.
3. Summoning Minions
The Netherbrain will recruit Illithids, Mind-controlled creatures, and more so that your party can be gradually whittled down. These enemies can put a lot of pressure fast on your team if not removed in a timely manner.
How to Beat the Netherbrain
Step 1: Clear the Adds First
As observed at the beginning of the Netherbrain BG3 fight, the Netherbrain will be able to call forth other enemies to join it in the battle. Just do not concentrate on the Netherbrain at first—eliminate the minions first in order that they won’t spoil the party. You and your tank should dive into these enemies, while you and other spell casters should nuke them from behind.
Step 2: Buff Your Party
Use major party supportive spells you have with you, such as Haste, Bless, and Protection from Evil and Good. All these spells are necessary if you want to stand a chance to counter the Netherbrain’s additional abilities of psychic damage and mind control.
Step 3: Positioning Is Key
Thanks to the AoE psychic abilities of the Netherbrain, make sure your party members are separated from one another in order to prevent all of them from being hit at once. The tank and melee characters should be kept up front to attack any minions or to maintain crowd control on the other group of monsters so that your damage dealers won’t be overwhelmed.
Step 4: Focus on the Netherbrain
Once the minions are defeated, concentrate as much firepower as you can on the Netherbrain. Both of its elements reduce your maximum health as well as incoming healing, and you should focus on pounding its health down with your spells and abilities as fast as possible. Basic spells like Magic Missile (which cannot be missed), a go-to spell, Eldritch Blast, and higher-level damage spells, Disintegrate, will aid in chipping away at the Netherbrain’s enormous number of hit points.
Step 5: Manage Healing and Restoration
During the fight, your party will receive massive amounts of damage from Netherbrain’s psychical assault, and whatever minions will still be alive. This model of the game should also incorporate healing spells such as Mass Cure Wounds and Healing Word so that characters do not fall in the battle. When a party member is charmed or has been forced to attack you, then you can cast Restoration spells or Remove Curse to get your party member back to normal.
Final Phase
As the Netherbrain’s health drops below 50%, it may enter a final phase, where it becomes more aggressive and its attacks more frequent. At this point, it may summon more powerful minions or hit your party with stronger psychic blasts.
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FAQs
It certainly will, but it is much more challenging than the usual instructions given to a beginner or an amateur. It’s advisable to have at least a few M, LM, or H spells, such as Disintegrate and Fireball, to cause fairly good amounts of damage. If you do not have high-damaging spells, you can use crowd control spells and your healing abilities to prolong your life.
There is advice to use Protection from Evil and Good in order to guard party members from mind control or have items that raise the Wisdom saving throws against the Netherbrain.
It is not mandatory to have one. However, having a character with apparent health and the ability to silence summons will definitely make the battle much, much easier. Arguably, Fighter, Barbarian, or Paladin in this position can significantly improve your party’s odds of overcoming the obstacles on their path.
Conclusion
The Netherbrain is the final episode of Baldur’s Gate 3. Still, after reading this guide, you should be ready to face the mind-controlling horror as well as use equipment, abilities, spells, and combinations described above to defeat it. One thing to note is that you should clear the ads, heal your party, and move away to avoid its big AoE damage. Fight well in your journey, and have fun completing your mission this third Baldur’s Gate.
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