Monster Hunter Wilds is all about crafting the best weapons to take down massive monsters, and elemental damage plays a big role in that. If you're looking to inflict poison damage and watch monsters slowly wither away (because why not make them suffer a little?), then you’ll need a Poison Sac.
But, as with most things in Monster Hunter, getting your hands on a MH Wilds Poison Sac isn't as simple as picking one off the ground. You’ll need to hunt a Rompopolo, a nasty little beast that thrives in the Oilwell Basin.
So, grab your antidotes, sharpen your weapon, and let's find out how to get Poison Sacs Monster Hunter Wilds and how to farm them efficiently!
Where to Get Poison Sacs in Monster Hunter Wilds If you’re deep into the game’s upgrade trees and wondering, Where do I even get this thing?—don’t worry, we got you. Monster Hunter Wilds Poison Sacs come exclusively from Rompopolos, which are commonly found in the Oilwell Basin, the third region you’ll explore in the main story.

While every Rompopolo kill gives you a chance at a Poison Sac, you can increase your odds by using a specific strategy.

Play Smart: Water Beats Poison
Destroy the Tail Wound for Bonus Drops

Poison Sacs aren’t just a cool trophy from Rompopolos; they’re an essential material for upgrading poison-based weapons.
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Hunting for Poison Sacs in Monster Hunter Wilds is pretty straightforward—find a Rompopolo, hit its tail, and carve it up. With a bit of patience (and some antidotes on hand), you’ll have all the Poison Sacs you need in no time.
Now, go out there and farm like a true hunter! And remember—don’t lick the Poison Sac. Just… don’t.
Poison Sacs can drop whenever you carve up a monster after killing it, although they are not always guaranteed, despite having a high drop rate. When combating Rompopolos, it is vital to have poison protection and antidotes on hand.
Poison Sac is a Substance in Monster Hunter Wilds. Materials like Poison Sac are unique items gained from looting the environment, fulfilling quests and objectives, and carving specific monsters. These items are essential for constructing and improving a hunter's gear.
Poison Sacs are dropped by Rompopolos, the most common monster in the Oilwell Basin.
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